Designed Biomolecules

Research Group

Structure-based design & synthesis of bioactive molecules

Computational study of biomolecular structure & dynamics

George Mavridis, MSc

Short Bio

George had been employed to our project “ARIA” for 10 months, for the biochemical study of HLA-A2 complexes with antigenic and extended peptides. Now he has a personal PhD scholarship from H.R.F.I. to complete his PhD studies.

February 2017-currently: PhD candidate at the department of Biotechnology of the Agricultural University of Athens in collaboration with the Protein Chemistry Laboratory of Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety of N.C.S.R. Demokritos

September 2013-September 2014: Master of Science in Drug Discovery and Translational Biology College of Science and Engineering, School of Biological Sciences, University of Edinburgh, United Kingdom.

December 2012: Bachelor degree in Biotechnology, Department of Biotechnology of Agricultural University of Athens

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Editors' Pick Highlight:

A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1

George Mavridis, Richa Arya, Alexander Domnick, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou‖, Anastasia Mpakali, Angelos Lelis, Dimitris Georgiadis, Robert Tampé, Athanasios Papakyriakou, Lawrence J. Stern and Efstratios Stratikos

Prior to immune system presentation by major histocompatibility complex (MHC) I, endoplasmic reticulum aminopeptidases (ERAPs) trim antigenic peptides. However, whether this is accomplished while peptides are bound to MHCI or unbound remains a point of debate. Here, Mavridis et al. thoroughly demonstrate that ERAP-mediated trimming cannot occur while peptides are bound, revealing that trimming is accomplished prior to MHCI binding. These results show that, once bound, peptides are protected from further modification, helping to settle the existing peptide-trimming controversy

Read the Editors’ Pick Highlight about this paper.
First author George Mavridis discusses his pursuit of a career studying proteins and pathogens.
Read the paper